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Abstract
Clear cell sarcoma of the kidney is the second most frequent malignant kidney tumor in pediatric age, after Wilms tumor. It is a neoplasm of difficult diagnosis, with a nonspecific clinical presentation such as palpable abdominal mass, abdominal pain, and hypertension and hematuria. The imaging characteristics of this lesion are nonspecific, so its diagnosis is made through the pathological study of the tumor. Its importance revolves around the diagnostic difficulty, since this tumor presents great histological variability and few adequate immunohistochemical markers. Treatment includes neoadjuvant and post-surgical chemotherapy, with a prognosis that improves if the disease is diagnosed early.
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References
Brok J, Treger TD, Gooskens SL, van den Heuvel-Eibrink MM, Pritchard-Jones K. Biology and treatment of renal tumours in childhood. Eur J Cancer [Internet]. 2016;68:179-95. https://doi.org/10.1016/j.ejca.2016.09.005
Chong WC, Cain JE. Lessons learned from the developmental origins of childhood renal cancer. Anat Rec. 2019;(March):1-17
Walke VA, Shende NY, Kumbhalkar DT. Renal clear cell sarcoma - Anaplastic variant: A rare entity. J Clin Diagnostic Res. 2017;11(1):ED10-1. https://doi.org/10.7860/JCDR/2017/23138.9214
Aw SJ, Chang KTE. Clear cell sarcoma of the kidney. Arch Pathol Lab Med. 2019;143(8):1022-6. https://doi.org/10.5858/arpa.2018-0045-RS
Astolfi A, Melchionda F, Perotti D, Fois M, Indio V, Urbini M, et al. Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney. Oncotarget. 2015;6(38):40934-9. https://doi.org/10.18632/oncotarget.5882
Gooskens SL, Gadd S, Guidry Auvil JM, Gerhard DS, Khan J, Patidar R, et al. TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney. Oncotarget. 2015;6(18):15828-41. https://doi.org/10.18632/oncotarget.4682
Chung EM, Graeber AR, Conran RM. Renal tumors of childhood: Radiologic-pathologic correlation part 1. the 1st decade. Radiographics. 2016;36(2):499-522. https://doi.org/10.1148/rg.2016150230
Özdemir ZC. Renal clear cell sarcoma presenting as a spontaneously renal hematoma: A rare presentation. North Clin Istanbul. 2017;5(1):60-3. https://doi.org/10.14744/nci.2017.75537
Zekri W, Yehia D, Elshafie MM, Zaghloul MS, El-Kinaai N, Taha H, et al. Bilateral clear cell sarcoma of the kidney. J Egypt Natl Canc Inst [Internet]. 2015;27(2):97-100. https://doi.org/10.1016/j.jnci.2015.03.002
Gooskens SL, Graf N, Furtwängler R, Spreafico F, Bergeron C, Ramírez-Villar GL, et al. Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol [Internet]. 2018;15(5):309-19. https://doi.org/10.1038/nrurol.2018.14
Vokuhl C. Rare childhood kidney tumors. Pathologe. 2019;40(6):600-8.https://doi.org/10.1007/s00292-019-0638-8
Koshinaga T, Takimoto T, Oue T, Okita H, Tanaka Y, Nozaki M, et al. Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG). Pediatr Blood Cancer. 2018;65(7):1-8. https://doi.org/10.1002/pbc.27056
Lang A, Dehner LP. Delayed Metastasis of Clear Cell Sarcoma of Kidney to Bladder After 7 Disease-Free Years. Fetal Pediatr Pathol [Internet]. 2018;37(2):126-33. https://doi.org/10.1080/15513815.2018.1435757
Roy A, Kumar V, Zorman B, Fang E, Haines KM, Doddapaneni HV, et al. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nat Commun [Internet]. 2015;6:1-7. https://doi.org/10.1038/ncomms9891
Naous R. TLE1 Positive Clear Cell Sarcoma of the Kidney: A Case Report and Review of the Literature. Case Rep Pathol. 2018;2018(Figure 3):1-5. https://doi.org/10.1155/2018/3462096
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