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El sarcoma de células claras renal es el segundo tumor renal maligno más frecuente en la edad pediátrica, después del tumor de Wilms. Es una neoplasia de difícil diagnóstico, con presentación clínica inespecífica como masa abdominal palpable, dolor abdominal e hipertensión y hematuria. Las características de imagen de esta lesión son inespecíficas, por lo que su diagnóstico se realiza mediante el estudio anatomopatológico del tumor. Su importancia gira en torno a la dificultad diagnóstica, ya que este tumor presenta gran variabilidad histológica y pocos marcadores inmunohistoquímicos adecuados. El tratamiento incluye quimioterapia neoadyuvante y post quirúrgica, con un pronóstico que mejora si el diagnóstico de la enfermedad es temprano.
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Brok J, Treger TD, Gooskens SL, van den Heuvel-Eibrink MM, Pritchard-Jones K. Biology and treatment of renal tumours in childhood. Eur J Cancer [Internet]. 2016;68:179-95. https://doi.org/10.1016/j.ejca.2016.09.005
Chong WC, Cain JE. Lessons learned from the developmental origins of childhood renal cancer. Anat Rec. 2019;(March):1-17
Walke VA, Shende NY, Kumbhalkar DT. Renal clear cell sarcoma - Anaplastic variant: A rare entity. J Clin Diagnostic Res. 2017;11(1):ED10-1. https://doi.org/10.7860/JCDR/2017/23138.9214
Aw SJ, Chang KTE. Clear cell sarcoma of the kidney. Arch Pathol Lab Med. 2019;143(8):1022-6. https://doi.org/10.5858/arpa.2018-0045-RS
Astolfi A, Melchionda F, Perotti D, Fois M, Indio V, Urbini M, et al. Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney. Oncotarget. 2015;6(38):40934-9. https://doi.org/10.18632/oncotarget.5882
Gooskens SL, Gadd S, Guidry Auvil JM, Gerhard DS, Khan J, Patidar R, et al. TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney. Oncotarget. 2015;6(18):15828-41. https://doi.org/10.18632/oncotarget.4682
Chung EM, Graeber AR, Conran RM. Renal tumors of childhood: Radiologic-pathologic correlation part 1. the 1st decade. Radiographics. 2016;36(2):499-522. https://doi.org/10.1148/rg.2016150230
Özdemir ZC. Renal clear cell sarcoma presenting as a spontaneously renal hematoma: A rare presentation. North Clin Istanbul. 2017;5(1):60-3. https://doi.org/10.14744/nci.2017.75537
Zekri W, Yehia D, Elshafie MM, Zaghloul MS, El-Kinaai N, Taha H, et al. Bilateral clear cell sarcoma of the kidney. J Egypt Natl Canc Inst [Internet]. 2015;27(2):97-100. https://doi.org/10.1016/j.jnci.2015.03.002
Gooskens SL, Graf N, Furtwängler R, Spreafico F, Bergeron C, Ramírez-Villar GL, et al. Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol [Internet]. 2018;15(5):309-19. https://doi.org/10.1038/nrurol.2018.14
Vokuhl C. Rare childhood kidney tumors. Pathologe. 2019;40(6):600-8.https://doi.org/10.1007/s00292-019-0638-8
Koshinaga T, Takimoto T, Oue T, Okita H, Tanaka Y, Nozaki M, et al. Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG). Pediatr Blood Cancer. 2018;65(7):1-8. https://doi.org/10.1002/pbc.27056
Lang A, Dehner LP. Delayed Metastasis of Clear Cell Sarcoma of Kidney to Bladder After 7 Disease-Free Years. Fetal Pediatr Pathol [Internet]. 2018;37(2):126-33. https://doi.org/10.1080/15513815.2018.1435757
Roy A, Kumar V, Zorman B, Fang E, Haines KM, Doddapaneni HV, et al. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nat Commun [Internet]. 2015;6:1-7. https://doi.org/10.1038/ncomms9891
Naous R. TLE1 Positive Clear Cell Sarcoma of the Kidney: A Case Report and Review of the Literature. Case Rep Pathol. 2018;2018(Figure 3):1-5. https://doi.org/10.1155/2018/3462096
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