Resumen
La menopausia es una etapa natural en la que no existe una receta o protocolo para establecer la indicación de la terapia de estrógeno. El estudio KEEPS enfatiza la necesidad de terapia de reemplazo hormonal. Es una decisión exclusiva entre el médico y el paciente, por lo que es de vital importancia como médico considerar sus implicaciones para la salud de forma individualizada.
Palabras clave
Terapia de reemplazo hormonal. estrógeno. estradiol. neurotransmisores. alzheimer.
Citas
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2. Zandi PP, Carlson MC, Plassman BL, et al. (2002) Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. Jama; 288: 21232129.
3. Bhavnani BR. (2003) Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's. J Steroid Biochem Mol Biol; 85: 473-482.
4. Sherwin BB. (2009) Estrogen therapy:is time of initiation critical for neuroprotection. Nat RevEndocrinol.620-627.PubMed:19844249.
5. Daniel jM, Bohacek J. (2010) The critical period hypothesis of estrogen effects on cognition:lnsights from basic research. Biochimica et Biophysica Acta. 1800:1068-1076.
6. Erickson Kl, Voss MW, Prakash RS, et al. (2006) A cross-sectional study of hormone treatment and hippocampal volume in postmenopausal women:evidence for a limited window of opportunity. Neuropsychology. 24:68-76. PubMed:3947.
7. Wharton W, Gleason CE, Lorenze KR, et al. (2009) Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease. Amy Transi Res.2:l 31-147.
2. Zandi PP, Carlson MC, Plassman BL, et al. (2002) Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. Jama; 288: 21232129.
3. Bhavnani BR. (2003) Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's. J Steroid Biochem Mol Biol; 85: 473-482.
4. Sherwin BB. (2009) Estrogen therapy:is time of initiation critical for neuroprotection. Nat RevEndocrinol.620-627.PubMed:19844249.
5. Daniel jM, Bohacek J. (2010) The critical period hypothesis of estrogen effects on cognition:lnsights from basic research. Biochimica et Biophysica Acta. 1800:1068-1076.
6. Erickson Kl, Voss MW, Prakash RS, et al. (2006) A cross-sectional study of hormone treatment and hippocampal volume in postmenopausal women:evidence for a limited window of opportunity. Neuropsychology. 24:68-76. PubMed:3947.
7. Wharton W, Gleason CE, Lorenze KR, et al. (2009) Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease. Amy Transi Res.2:l 31-147.
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