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Abstract
The use of antineoplastic drugs increases the risk of thromboembolic disease in cancer patients. The first months of treatment represent the greatest thrombotic risk, and major medical comorbidities and/or infectious complications also increase this risk. Combining immunomodulators with dexamethasone or cytotoxic chemotherapy increases the incidence of thrombosis in the setting of multiple myeloma or non-Hodgkin's lymphoma. The use of platinum salts, fluoropyrimidines, and L-asparaginase have also been identified as risk factors for thromboembolic disease. In terms of targeted therapies, epidermal growth factor receptor inhibitors have been associated with increased thromboembolic events. For their part, vascular endothelial growth factor inhibitors, specifically monoclonal antibodies, have been associated with venous and arterial thrombosis. High-dose corticosteroids treatments increase the incidence of thromboembolism.
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References
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