How to Cite
1.
Todorov T. Paraquat neurotoxicity. Rev.méd.sinerg. [Internet]. 2018Feb.1 [cited 2024Nov.22];3(2):3-6. Available from: https://revistamedicasinergia.com/index.php/rms/article/view/115
Abstract
Paraquat (1-1´-dimetil-4-4-bipyridylium dichloride) is widely used in Costa Rica as a herbicide and is marketed as a 20% aqueous solution (Gramoxone). Paraquat poisoning carries a high mortality rate. Severe paraquat poisoning is characterized by multiple-organ involvement, mainly the lungs, kidneys, liver. The lung is a major target organ in paraquat poisoning, and respiratory failure from acute pulmonary fibrosis is the most common cause of death. Paraquat is neurotoxic , but the neurotoxic effect of paraquat in acute intoxication in humans is not yet clear.
Keywords
Paraquat. intoxication. neurotoxicity. neuroimaging.
References
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2. Stelmashook EV, Isaev NK, Zorov DB. Paraquat potentiates glutamate toxicity in immature cultures of cerebellar granule neurons. 2007; (1-3): 82-8.
3. Niso-Santano M, Moran J M, Garcia-Rubio L, GomezMartin A, Gonzalez-Polo R A, Low concentrations of paraquat induces early activation of extracellular signalregulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquatinduced cell death. 2006; (2): 507-15.
4. Chen Q, Niu Y, Zhang R, Guo H, Gao Y, The toxic influence of paraquat on hippocampus of mice: involvement of oxidative stress. 2010; (3): 310-6. 5. Peng J, Stevenson FF, Oo ML, Andersen JK. Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation 2009; Free Radic Biol Med (2): 312-20.
6. Kang MJ, Gil SJ, Koh HC. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. 2009; (2): 148-52.
7. Ren JP, Zhao YW, Sun XJ. Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice. 2009; 122 (19): 2366-71.
8. Dart RC, McGuigan MA. Pesticides. 3 ed. Philadelphia: Lippincott Williams and Wilkins; 2004. 1475534.
9. Wu B, Song B, Yang H, Huang B, Chi B, Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology 2013; : 62-70.
10. Wang Q, Liu S, Hu D, Wang Z, Wang L, . Identification of apoptosis and macrophage migration events in paraquatinduced oxidative stress using a zebrafish model. Life.Science 2016; (16): 30365-4
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