Cómo citar
1.
Todorov T. Neurotoxicidad del Paraquat. Rev.méd.sinerg. [Internet]. 1 de febrero de 2018 [citado 22 de diciembre de 2024];3(2):3-6. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/115
Resumen
El Paraquat es un herbicida bipiridílico que se presenta en forma líquida en concentraciones del 20% para uso agrícola. Su nombre químico es eI 1-1´-dimetil-4-4- bipiridilo, con el nombre comercial de Gramoxone. La intoxicación por Paraquat tiene una tasa de mortalidad elevada. El pulmón es el órgano diana en la intoxicación por Paraquat y la insuficiencia respiratoria con fibrosis pulmonar aguda es la causa más común de muerte. Interesa conocer cuál es la afectación del Paraquat en el sistema nervioso central. Dada su alta toxicidad, si la dosis es letal la mayor de los pacientes mueren en 48 horas y no se observan efectos neurológicos.
Palabras clave
Paraquat. intoxicación. neurotoxicidad. neuroimagenes.
Citas
1. Syed Hassan Mehdi, Qamar A. Paraquat-Induced Ultrastructural Changes and DNA Damage in the Nervous System Is Mediated via Oxidative-Stress-Induced Cytotoxicity in Drosophila melanogaster. Toxicological sciences 2013; (2): 355-65.
2. Stelmashook EV, Isaev NK, Zorov DB. Paraquat potentiates glutamate toxicity in immature cultures of cerebellar granule neurons. 2007; (1-3): 82-8.
3. Niso-Santano M, Moran J M, Garcia-Rubio L, GomezMartin A, Gonzalez-Polo R A, Low concentrations of paraquat induces early activation of extracellular signalregulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquatinduced cell death. 2006; (2): 507-15.
4. Chen Q, Niu Y, Zhang R, Guo H, Gao Y, The toxic influence of paraquat on hippocampus of mice: involvement of oxidative stress. 2010; (3): 310-6. 5. Peng J, Stevenson FF, Oo ML, Andersen JK. Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation 2009; Free Radic Biol Med (2): 312-20.
6. Kang MJ, Gil SJ, Koh HC. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. 2009; (2): 148-52.
7. Ren JP, Zhao YW, Sun XJ. Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice. 2009; 122 (19): 2366-71.
8. Dart RC, McGuigan MA. Pesticides. 3 ed. Philadelphia: Lippincott Williams and Wilkins; 2004. 1475534.
9. Wu B, Song B, Yang H, Huang B, Chi B, Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology 2013; : 62-70.
10. Wang Q, Liu S, Hu D, Wang Z, Wang L, . Identification of apoptosis and macrophage migration events in paraquatinduced oxidative stress using a zebrafish model. Life.Science 2016; (16): 30365-4
2. Stelmashook EV, Isaev NK, Zorov DB. Paraquat potentiates glutamate toxicity in immature cultures of cerebellar granule neurons. 2007; (1-3): 82-8.
3. Niso-Santano M, Moran J M, Garcia-Rubio L, GomezMartin A, Gonzalez-Polo R A, Low concentrations of paraquat induces early activation of extracellular signalregulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquatinduced cell death. 2006; (2): 507-15.
4. Chen Q, Niu Y, Zhang R, Guo H, Gao Y, The toxic influence of paraquat on hippocampus of mice: involvement of oxidative stress. 2010; (3): 310-6. 5. Peng J, Stevenson FF, Oo ML, Andersen JK. Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation 2009; Free Radic Biol Med (2): 312-20.
6. Kang MJ, Gil SJ, Koh HC. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. 2009; (2): 148-52.
7. Ren JP, Zhao YW, Sun XJ. Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice. 2009; 122 (19): 2366-71.
8. Dart RC, McGuigan MA. Pesticides. 3 ed. Philadelphia: Lippincott Williams and Wilkins; 2004. 1475534.
9. Wu B, Song B, Yang H, Huang B, Chi B, Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology 2013; : 62-70.
10. Wang Q, Liu S, Hu D, Wang Z, Wang L, . Identification of apoptosis and macrophage migration events in paraquatinduced oxidative stress using a zebrafish model. Life.Science 2016; (16): 30365-4
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