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Abstract
Anovulatory infertility is a common complication associated with polycystic ovary syndrome. Health optimization is the first step in the management of this pathology, specially focused on lifestyle changes
and optimal body mass index. About pharmacotherapy, clomiphene citrate is used worldwide as a first line treatment to induce ovulation. However, letrozol and a combination of clomiphene citrate plus metformin have shown to be superior to clomiphene citrate in monotherapy, concerning fertility. These are still considered second line treatment due to lack of consensus. Exogenous gonadotropins and laparoscopic ovarian drilling are used when first-line treatment resistance is determined. Once first- and second-line treatment have failed, in-vitro fertilization is an option. Other drugs are being studied to determine their efficacy on this pathology, such as glucagon-like peptide 1 receptor agonists and inositol stereoisomers, but higher quality studies are still required.
Keywords
References
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