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Abstract
Amyotrophic lateral sclerosis is a progressive disease characterized by degeneration of motor neurons in the brain and spinal cord. There are two fundamental forms of this disease: the sporadic form and the familial form. There is still no clarity about its etiology. Clinical manifestations include signs of damage to the upper and lower motor neurons, both in the extremities and in the bulbar musculature. The diagnosis continues to be fundamentally clinical, supported by neurophysiological studies. There is no curative treatment. Riluzole is the first-line drug treatment that has been shown to delay the normal course of the disease. Edaravone is approved by the FDA for use in this disease in conjunction with riluzole.
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References
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