Abstract
The pemphigoid gestacionalis is a rare, pruritic, skin disease, autoinmune, and it belongs to the pregnancy-specific dermatoses. PG mainly develops between the second, third trimester, and/or immediate postpartum, with a periumbilical pruritic vesiculobullous rash. The diagnosis is based on the clinical presentation, histological findings of the lesions, direct immunofluorescence and ELISA. The majority of the cases are treated with antihistamines and corticosteroids. The PG is associated with an increased morbidity for pregnant women and fetal risks, for that reason, it is important to recognize this pathology for adequate interdisciplinary approach between dermatology, obstetrics and pathologic anatomy.
Keywords
References
Lobato-Berezo A, Fernández Figueras M, Moreno Romero J, Pujol R. Penfigoide gestacional simulando un eritema multiforme con afectación mucosa. Actas Dermo-Sifiliográficas. 2019 Oct;110(8):696-697. https://doi.org/10.1016/j.ad.2018.02.038
Yang A, Uhlenhake E, Murrell DF. Pemphigoid gestationis and intravenous immunoglobulin therapy. International Journal of Women's Dermatology. 2018 09;4(3):166-169. https://doi.org/10.1016/j.ijwd.2018.03.007
Sävervall C, Sand FL, Thomsen SF. Pemphigoid gestationis: current perspectives. Clinical, Cosmetic and Investigational Dermatology. 2017 Nov;Volume 10:441-449. https://doi.org/10.2147/ccid.s128144
Kukkamalla R, Bayless P. Pemphigoid Gestationis. Clinical Practice and Cases in Emergency Medicine. 2019;3(1):79-80. https://doi.org/10.5811/cpcem.2018.11.39258
Huilaja L, Mäkikallio K, Hannula-Jouppi K, Väkevä L, Höök-Nikanne J, Tasanen K. Cyclosporine Treatment in Severe Gestational Pemphigoid. Acta Dermato Venereologica. 2015;95(5):593-595. https://doi.org/10.2340/00015555-2032
Hallaji Z, Mortazavi H, Ashtari S, Nikoo A, Abdollahi M, Nasimi M. Pemphigoid gestationis: Clinical and histologic features of twenty-three patients. International Journal of Women's Dermatology. 2017 06;3(2):86-90. https://doi.org/10.1016/j.ijwd.2016.11.004
Singla A. Pregnancy with Pemphigoid Gestationis: A Rare Entity. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. 2016;. https://doi.org/10.7860/jcdr/2016/19491.8215
Mehta N, Chen KK, Kroumpouzos G. Skin disease in pregnancy: The approach of the obstetric medicine physician. Clinics in Dermatology. 2016 05;34(3):320-326. https://doi.org/10.1016/j.clindermatol.2016.02.003
Keltz M. Dermatoses of pregnancy. [Internet]. UpToDate. [Internet]. [Consultado 3 Oct 2019].2018; Disponible en: https://www.uptodate.com/contents/dermatoses-of-pregnancy
Hidalgo V. Penfigoide gestacional. Revista medica de costa rica y centroamerica LXXIV. 2017;624:137-139.
Gonzalo García I, Biain Ciganda A, Bustinza Beaskoetxea Z, Martín Saez E, Obregon Martinez E, Martinez-Guisasola J. Penfigoide gestacional. Clínica e Investigación en Ginecología y Obstetricia. 2017 01;44(1):31-34. https://doi.org/10.1016/j.gine.2015.10.005
Santos S, Benavente F, Garcia M, Moneva L, Sanchis c, Mateu A. Urticarial Lesions in a Pregnant Woman. Acta Dermatovenerol Croat. 2018;26:71-72.
Sadik CD, Lima AL, Zillikens D. Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis. Clinics in Dermatology. 2016 05;34(3):378-382. https://doi.org/10.1016/j.clindermatol.2016.02.010
Papapanagiotou IK, Tsagouri S, Liakou CG, Besharat A, Vogiatzis N, Ntzeros K, Petrakis E, Koutroumanis P, Thomakos N, Loutradis D. Pemphigoid gestationis. Clinical Case Reports. 2018 05 07;6(7):1364-1365. https://doi.org/10.1002/ccr3.1545
Soares KS, Lehmann PM, Hofmann SC. Pemphigoid gestationis with lethal fetal malformation and postpartum persistence. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2018 06;16(6):775-777. https://doi.org/10.1111/ddg.13540
Fania L, Guerriero C, Ricci F, Gagliano MF, De Simone C. Herpes gestationis and oral contraceptive: Case report and review of the literature. Dermatologic Therapy. 2017 07 21;30(5):e12518. https://doi.org/10.1111/dth.12518
Kanwar A. Pemphigoid gestationis. British Journal of Dermatology. 2015 01;172(1):6-7. https://doi.org/10.1111/bjd.13457
Nguyen T, Alraqum E, Razzaque Ahmed A. Positive clinical outcome with IVIg as monotherapy in recurrent pemphigoid gestationis. International Immunopharmacology. 2015 05;26(1):1-3. https://doi.org/10.1016/j.intimp.2015.02.038
Zubor P, Svecova I, Moricova P, Pec J, Adamicova K, Danko J. Early flare-up of severe Herpes gestationis (Pemphigoid gestationis) and successfull prolonged treatment: A case report. Journal of Obstetrics and Gynaecology. 2017;37(6):824-826. https://doi.org/10.1080/01443615.2017.1305334
Ingen-Housz-Oro S, Sbidian E, Ortonne N, Poirier E, Chosidow O, Wolkenstein P. Pemphigoid gestationis revealing a denial of pregnancy. Journal of the European Academy of Dermatology and Venereology. 2015 08 24;30(8):1411-1413. https://doi.org/10.1111/jdv.13257