How to Cite
1.
Hines Chaves KD, Zumbado Vásquez R, Castro Corrales V. Chagas’ Heart Disease. Rev.méd.sinerg. [Internet]. 2019May1 [cited 2024Nov.22];4(5):101 - 10. Available from: https://revistamedicasinergia.com/index.php/rms/article/view/212
Abstract
Chagas disease is an infectious disorder caused by the protozoan parasite Trypanosoma cruzi. Due to its estimated burden of disease it is considered the most important parasitic disease in the West. T. cruzi is transmitted mainly through a vector, its main vector is Triatoma dimidiata. When T. cruzi infects its host, it destroys the cells it infects, causing an inflammatory response that affects different organs and tissues. Due to the myocardium’s susceptibility and its low regeneration capacity, the heart is one of the main implicated organs. Chronic Chagasic Heart Disease is the most severe complication of the disease, with a great range of manifestations, going anywhere from an asymptomatic infection up to heart failure with dilated myocardiopathy and sudden death. To diagnose this disease, there are different techniques that can be used according to the phase of the disease. In addition, studies are used for evaluation, in order to accurately characterize the heart condition. The treatment goal is to control the heart failure and prevent thromboembolic events. Specifically, for the treatment against infection, nifurtimox and benznidazole have been proven effective against T. cruzi.
Keywords
Trypanosoma cruzi. Chagas disease. cardiomyopathies. triatoma. heart diseases.
References
1. Bern C. Chagas’ Disease. Longo DL. New England Journal of Medicine. 2015 07 30;373(5):456-466. https://doi.org/10.1056/nejmra1410150
2. Rivero I. Enfermedad de Chagas. Revista Medica De Costa Rica Y Centroamerica. (2016); 83 (619): 297 – 301p. Disponible en: http://revistamedicacr.com/index.php/rmcr/article/view/134/0
3. Lewis MD, Francisco AF, Taylor MC, Jayawardhana S, Kelly JM. Host and parasite genetics shape a link betweenTrypanosoma cruziinfection dynamics and chronic cardiomyopathy. Cellular Microbiology. 2016 05 25; 18(10):1429-1443 p. https://doi.org/10.1111/cmi.12584
4. Imai K, Maeda T, Sayama Y, Mikita K, Fujikura Y, Misawa K, Nagumo M, Iwata O, Ono T, Kurane I, Miyahira Y, Kawana A, Miura S. Mother-to-Child Transmission of Congenital Chagas Disease, Japan. Emerging Infectious Diseases. 2014 01;20(1):146-148. https://doi.org/10.3201/eid2001.131071
5. Clark EH, Sherbuk J, Okamoto E, Jois M, Galdos-Cardenas G, Vela-Guerra J, Menacho-Mendez GS, Bozo-Gutierrez RW, Fernandez AB, Crawford TC, Colanzi R, Gilman RH, Bern C, . Hyperendemic Chagas Disease and the Unmet Need for Pacemakers in the Bolivian Chaco. Debrabant A. PLoS Neglected Tropical Diseases. 2014 06 05;8(6):e2801. https://doi.org/10.1371/journal.pntd.0002801
6. Moreno-Medina E, Valerio-Campos I, Goyenaga-Castro P. Miocarditis y miocardiopatía dilatada por Trypanosoma cruzi: Reporte de un caso. Parasitología latinoamericana. 2007 Dec; 62(3-4): 148 -153 p. https://doi.org/10.4067/s0717-77122007000200008
7. Yoshioka K, Provedor E, Manne-Goehler J. The resilience of Triatoma dimidiata: An analysis of reinfestation in the Nicaraguan Chagas disease vector control program (2010–2016). Oliveira PL. PLOS ONE. 2018 08 23;13(8):e0202949. https://doi.org/10.1371/journal.pone.0202949
8. Silva-dos-Santos D, Barreto-de-Albuquerque J, Guerra B, Moreira OC, Berbert LR, Ramos MT, Mascarenhas BAS, Britto C, Morrot A, Serra Villa-Verde DM, Garzoni LR, Savino W, Cotta-de-Almeida V, Meis JD. Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues. Tanowitz HB. PLOS Neglected Tropical Diseases. 2017 04 05;11(4):e0005507. https://doi.org/10.1371/journal.pntd.0005507
9. Salazar-Schettino PM, Bucio-Torres MI, Cabrera-Bravo M, de Alba-Alvarado MC, Castillo-Saldaña R, Zenteno-Galindo E, et al. Enfermedad de Chagas en México. Revista de la Facultad de Medicina de la UNAM [Internet]. 2016 May – Junio [citado 2019 Mar 27]; 59(3): 6–16. Disponible en: http://search.ebscohost.com.ezproxy.sibdi.ucr.ac.cr:2048/login.aspx?direct=true&db=a9h&AN=116613805&site=ehost-live&scope=site
10. Gómez-Palacio A, Arboleda S, Dumonteil E, Townsend Peterson A. Ecological niche and geographic distribution of the Chagas disease vector, Triatoma dimidiata (Reduviidae: Triatominae): Evidence for niche differentiation among cryptic species. Infection, Genetics and Evolution. 2015 Dec;36:15-22. https://doi.org/10.1016/j.meegid.2015.08.035
11. Pérez Yanez LM, Gutiérrez López A, Rodríguez Blanco S, Gil SA. Enfermedad de Chagas. Amenaza en sombras para los corazones de la América Latina. Revista Cubana de Medicina [Internet]. 2017 Jan [citado 2019 Mar 28]; 56(1): 50–68 p. Disponible en: http://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=77870
12. Pinazo M, Lacima G, Elizalde J, Posada E, Gimeno F, Aldasoro E, Valls M, Gascon J. Characterization of Digestive Involvement in Patients with Chronic T. cruzi Infection in Barcelona, Spain. PLoS Neglected Tropical Diseases. 2014 08 21; 8(8): e3105. https://doi.org/10.1371/journal.pntd.0003105
13. Peixoto GDL, Martinelli Filho M, Siqueira SFD, Nishioka SAD, Pedrosa AAA, Teixeira RA, Costa R, Kalil Filho R, Ramires JAF. Predictors of death in chronic Chagas cardiomyopathy patients with pacemaker. International Journal of Cardiology. 2018 01; 250: 260-265. https://doi.org/10.1016/j.ijcard.2017.10.031
14. Assunção AN, Jerosch-Herold M, Melo RL, Mauricio AV, Rocha L, Torreão JA, Fernandes F, Ianni BM, Mady C, Ramires JAF, Kalil-Filho R, Rochitte CE. Chagas’ heart disease: gender differences in myocardial damage assessed by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance. 2016 Nov 28; 18: 88. https://doi.org/10.1186/s12968-016-0307-5
15. Borges JP, Mendes FDSNS, Lopes GDO, Sousa ASD, Mediano MFF, Tibiriçá E. Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?. International Journal of Cardiology. 2018 08; 265: 35-37. https://doi.org/10.1016/j.ijcard.2018.04.133
16. Cucunubá ZM, Okuwoga O, Basáñez M, Nouvellet P. Increased mortality attributed to Chagas disease: a systematic review and meta-analysis. Parasites & Vectors. 2016 01 27; 9: 42. https://doi.org/10.1186/s13071-016-1315-x
17. Marchiori E, . Chagas disease: a tropical infection of interest to the radiologist. Radiologia Brasileira. 2016 Dec; 49(6): 5-6. https://doi.org/10.1590/0100-3984.2016.49.6e1
18. Lee-Felker S, Thomas M, Felker E, Traina M, Salih M, Hernandez S, Bradfield J, Lee M, Meymandi S. Value of cardiac MRI for evaluation of chronic Chagas disease cardiomyopathy. Clinical Radiology. 2016 06; 71(6): 618.e1-618.e7. https://doi.org/10.1016/j.crad.2016.02.015
19. Torreão JA, Ianni BM, Mady C, Naia E, Rassi CH, Nomura C, Parga JR, Avila LF, Ramires JAF, Kalil-Filho R, Rochitte CE. Myocardial tissue characterization in Chagas’ heart disease by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance. 2015 Nov 18; 17: 97. https://doi.org/10.1186/s12968-015-0200-7
2. Rivero I. Enfermedad de Chagas. Revista Medica De Costa Rica Y Centroamerica. (2016); 83 (619): 297 – 301p. Disponible en: http://revistamedicacr.com/index.php/rmcr/article/view/134/0
3. Lewis MD, Francisco AF, Taylor MC, Jayawardhana S, Kelly JM. Host and parasite genetics shape a link betweenTrypanosoma cruziinfection dynamics and chronic cardiomyopathy. Cellular Microbiology. 2016 05 25; 18(10):1429-1443 p. https://doi.org/10.1111/cmi.12584
4. Imai K, Maeda T, Sayama Y, Mikita K, Fujikura Y, Misawa K, Nagumo M, Iwata O, Ono T, Kurane I, Miyahira Y, Kawana A, Miura S. Mother-to-Child Transmission of Congenital Chagas Disease, Japan. Emerging Infectious Diseases. 2014 01;20(1):146-148. https://doi.org/10.3201/eid2001.131071
5. Clark EH, Sherbuk J, Okamoto E, Jois M, Galdos-Cardenas G, Vela-Guerra J, Menacho-Mendez GS, Bozo-Gutierrez RW, Fernandez AB, Crawford TC, Colanzi R, Gilman RH, Bern C, . Hyperendemic Chagas Disease and the Unmet Need for Pacemakers in the Bolivian Chaco. Debrabant A. PLoS Neglected Tropical Diseases. 2014 06 05;8(6):e2801. https://doi.org/10.1371/journal.pntd.0002801
6. Moreno-Medina E, Valerio-Campos I, Goyenaga-Castro P. Miocarditis y miocardiopatía dilatada por Trypanosoma cruzi: Reporte de un caso. Parasitología latinoamericana. 2007 Dec; 62(3-4): 148 -153 p. https://doi.org/10.4067/s0717-77122007000200008
7. Yoshioka K, Provedor E, Manne-Goehler J. The resilience of Triatoma dimidiata: An analysis of reinfestation in the Nicaraguan Chagas disease vector control program (2010–2016). Oliveira PL. PLOS ONE. 2018 08 23;13(8):e0202949. https://doi.org/10.1371/journal.pone.0202949
8. Silva-dos-Santos D, Barreto-de-Albuquerque J, Guerra B, Moreira OC, Berbert LR, Ramos MT, Mascarenhas BAS, Britto C, Morrot A, Serra Villa-Verde DM, Garzoni LR, Savino W, Cotta-de-Almeida V, Meis JD. Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues. Tanowitz HB. PLOS Neglected Tropical Diseases. 2017 04 05;11(4):e0005507. https://doi.org/10.1371/journal.pntd.0005507
9. Salazar-Schettino PM, Bucio-Torres MI, Cabrera-Bravo M, de Alba-Alvarado MC, Castillo-Saldaña R, Zenteno-Galindo E, et al. Enfermedad de Chagas en México. Revista de la Facultad de Medicina de la UNAM [Internet]. 2016 May – Junio [citado 2019 Mar 27]; 59(3): 6–16. Disponible en: http://search.ebscohost.com.ezproxy.sibdi.ucr.ac.cr:2048/login.aspx?direct=true&db=a9h&AN=116613805&site=ehost-live&scope=site
10. Gómez-Palacio A, Arboleda S, Dumonteil E, Townsend Peterson A. Ecological niche and geographic distribution of the Chagas disease vector, Triatoma dimidiata (Reduviidae: Triatominae): Evidence for niche differentiation among cryptic species. Infection, Genetics and Evolution. 2015 Dec;36:15-22. https://doi.org/10.1016/j.meegid.2015.08.035
11. Pérez Yanez LM, Gutiérrez López A, Rodríguez Blanco S, Gil SA. Enfermedad de Chagas. Amenaza en sombras para los corazones de la América Latina. Revista Cubana de Medicina [Internet]. 2017 Jan [citado 2019 Mar 28]; 56(1): 50–68 p. Disponible en: http://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=77870
12. Pinazo M, Lacima G, Elizalde J, Posada E, Gimeno F, Aldasoro E, Valls M, Gascon J. Characterization of Digestive Involvement in Patients with Chronic T. cruzi Infection in Barcelona, Spain. PLoS Neglected Tropical Diseases. 2014 08 21; 8(8): e3105. https://doi.org/10.1371/journal.pntd.0003105
13. Peixoto GDL, Martinelli Filho M, Siqueira SFD, Nishioka SAD, Pedrosa AAA, Teixeira RA, Costa R, Kalil Filho R, Ramires JAF. Predictors of death in chronic Chagas cardiomyopathy patients with pacemaker. International Journal of Cardiology. 2018 01; 250: 260-265. https://doi.org/10.1016/j.ijcard.2017.10.031
14. Assunção AN, Jerosch-Herold M, Melo RL, Mauricio AV, Rocha L, Torreão JA, Fernandes F, Ianni BM, Mady C, Ramires JAF, Kalil-Filho R, Rochitte CE. Chagas’ heart disease: gender differences in myocardial damage assessed by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance. 2016 Nov 28; 18: 88. https://doi.org/10.1186/s12968-016-0307-5
15. Borges JP, Mendes FDSNS, Lopes GDO, Sousa ASD, Mediano MFF, Tibiriçá E. Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?. International Journal of Cardiology. 2018 08; 265: 35-37. https://doi.org/10.1016/j.ijcard.2018.04.133
16. Cucunubá ZM, Okuwoga O, Basáñez M, Nouvellet P. Increased mortality attributed to Chagas disease: a systematic review and meta-analysis. Parasites & Vectors. 2016 01 27; 9: 42. https://doi.org/10.1186/s13071-016-1315-x
17. Marchiori E, . Chagas disease: a tropical infection of interest to the radiologist. Radiologia Brasileira. 2016 Dec; 49(6): 5-6. https://doi.org/10.1590/0100-3984.2016.49.6e1
18. Lee-Felker S, Thomas M, Felker E, Traina M, Salih M, Hernandez S, Bradfield J, Lee M, Meymandi S. Value of cardiac MRI for evaluation of chronic Chagas disease cardiomyopathy. Clinical Radiology. 2016 06; 71(6): 618.e1-618.e7. https://doi.org/10.1016/j.crad.2016.02.015
19. Torreão JA, Ianni BM, Mady C, Naia E, Rassi CH, Nomura C, Parga JR, Avila LF, Ramires JAF, Kalil-Filho R, Rochitte CE. Myocardial tissue characterization in Chagas’ heart disease by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance. 2015 Nov 18; 17: 97. https://doi.org/10.1186/s12968-015-0200-7
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