How to Cite
1.
Mora Agüero S de los Ángeles, Zeledón Aguilera AS, Vargas Rubio T. Oxidative stress and antioxidants: effects on pregnancy. Rev.méd.sinerg. [Internet]. 2019May1 [cited 2024Nov.22];4(5):89 - 100. Available from: https://revistamedicasinergia.com/index.php/rms/article/view/211
Abstract
Oxygen is an important element on which the life of aerobic organisms depends. However, it is also responsible for the degeneration that can occur at the cellular level in our organism, generating organic and functional alterations. It can be affirmed that in slight quantities, free radicals are not harmful to the human body and are rather part of beneficial processes for the organism, but as they increase and accumulate, oxidative stress is generated, this assist the progression and evolution of degenerative diseases. In healthy pregnancy it is normal that there is an increase in the production of free radicals due to placental activity, however this may exceed oxidative stress, if harmful endogenous or exogenous stimuli that contribute to the loading of free radicals are present, they may be develop complications such as infertility or subfertility, abortion, preeclampsia, gestational diabetes or premature rupture of membranes. It is important to maintain an antioxidant-antioxidant balance due to the unfavorable outcomes, in the mother or fetus, that the aforementioned pathologies may have.
Keywords
Antioxidants. free radicals. pregnancy. oxidative stress. reactive oxygen species.
References
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25. Mistry, H., Williams, P. The Importance of Antioxidant Micronutrients in Pregnancy. Oxid Med Cell Longev. 2011; 2011: ID 841749. https://doi.org/10.1155/2011/841749
26. Zachara B, Wardak C, Didkowski W, Maciag A, Marchaluk E. Changes in blood selenium and glutathione concentrations and glutathione peroxidase activity in human pregnancy. Gynecol Obstet Invest. 1993; 35(1): 12-17. https://doi.org/10.1159/000292655
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28. Wang H, Hu Y, Hao J, Chen Y, Su P, Wang Y, Yu Y, et al. Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Sci Rep. 2015; 5: 11626. https://doi.org/10.1038/srep11262
2. DrÖge W. Free Radicals in the Physiological Control of Cell Function. Physiol Rev. 2001; 82(1): 47-95. https://doi.org/10.1152/physrev.00018.2001
3. Saavedra O, Jimenéz E, Guapillo M, Ceballos G, Méndez E. Radicales libres y su papel en las enfermedades crónico degenerativas. Med UV. 2010; 10(2): 32-39. Disponible en: https://www.uv.mx/rm/num_anteriores/revmedica_vol10_num2/articulos/radicales.pdf
4. Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, et al. Oxidative Stress, Prooxidantes, and Antioxidants: The Interplay. Biomed Res Int. 2014; 2014: ID 761264. http://dx.doi.org/10.1155/2014/761264
5. Coronado M, Vega y León Salvador, Gutiérrez T Rey, Vázquez Marcela, Radilla V Claudia. Antioxidantes: perspectiva actual para la salud humana. Rev. chil. nutr. 2015; 42(2): 206-212. http://dx.doi.org/10.4067/S0717-75182015000200014
6. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017; 2017: ID 8416763. https://doi.org/10.1155/2017/8416763
7. Rajendran P, Nandakumar R, Rengarajan T, Palaniswami R, Gnanadhas E, Lakshminarasaiah U, et al. Antioxidants and human diseases. Clin Chim Acta. 2014; (346): 332-347. https://doi.org/10.1016/j.cca.2014.06.004
8. Venereo Gutiérrez Justo R. Daño oxidativo, radicales libres y antioxidantes. Rev Cub Med Mil. 2002; 31(2): 126-133. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572002000200009
9. Lu J, Lin P, Yao Q, Chen C. Chemical and molecular mechanisms of antioxidants. J Cell Mol Med. 2010; 14(4): 840-860. https://doi.org/10.1111/j.1582-4934.2009.00897.x
10. Martínez G. Especies reactivas del oxígeno y balance redox, parte I: aspectos básicos y principales especies reactivas del oxígeno. Rev Cubana Farm. 2005; 39(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152005000300009&lng=es
11. Salim S. Oxidative Stress and Psychological Disorders. Curr Neuropharmacol. 2014; 12(2): 140-147. https://doi.org/10.2174/1570159X11666131120230309
12. Bahorun T, Soobrattee M, Luximon-Ramma V, Auroma O. Free radicals and antioxidants in cardiovascular health and disease. Internet Journal of Medical Update. 2006; 1(2): 24-40. http://dx.doi.org/10.4314/ijmu.v1i2.39839
13. MacNee W. Oxidative Stress and lung inflammation in airways disease. Eur J Pharmacol. 2001; 429(1-3): 195-207. https://doi.org/10.1016/S0014-2999(01)01320-6
14. Myatt, L., Cui, X. Oxidative stress in the placenta. Histochem Cell Biol. 2004; 122 (4): 369-382. https://doi.org/10.1007/s00418-004-0677-x
15. Leal C, Schetinger M, Leal D, Morsch V, da Silva A, Rezer J, de Barios A, Jaques J. Oxidative stress and antioxidant defenses in pregnant women. Redox Rep. 2011; 16(6): 230-236. https://doi.org/10.1179/1351000211Y.0000000013
16. Barrios de Tomasi J, Barrios de Tomasi E, Vergara J. Efecto de la obesidad en la reproducción femenina. Rev Mex Cienc Farm. 2013; 44( 3 ): 8-18. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-01952013000300002&lng=es
17. Toy H, Camuzcuoglu H, Camuzcuoglu A, Celik H, Aksoy N. Decreased Serum Prolidase Activity and Increased Oxidative Stress in Early Pregnancy Loss. Gynecol Obstet Invest. 2010; 69(2): 122-127. https://doi.org/10.1159/000262608
18. Abalos E, Cuesta C, Grosso A, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013; 170(1): 1-7. https://doi.org/10.1016/j.ejogrb.2013.05.005
19. Kaufmann P, Blacks S, Huppertz B. Endovascular Trophoblast Invasion: Implications of the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia. Biol Reprod. 2003; 69(1): 1-7. https://doi.org/10.1095/biolreprod.102.014977
20. Sánchez-Aranguren L, Prada C, Riaño-Medina C, López M. Endotelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol. 2014; 5: 372. https://doi.org/10.3389/fphys.2014.00372
21. Alfadhli E. Gestational Diabetes mellitus. Saudi Med J. 2015; 36(4): 399-406. https://doi.org/10.15537/smj.2015.4.10307
22. Chen X, Scholl T. Oxidative Stress: Changes in pregnancy and Gestational Diabetes Mellitus. Curr Diab Rep. 2005; 5(4): 282-288. https://doi.org/10.1007/s11892-005-0024-1
23. Menon R, Richardson R. Preterm Prelabor Rupture of Membranes: A disease of fetal of the fetal membranes. Semin Perinatol. 2017; 41(7): 409-419. https://doi.org/ 10.1053/j.semperi.2017.07.012
24. Longini M, Perrone S, Vezzosi P, Marzocchi B, Kenanidis A, Centini G, Rosignoli L, Buonocore J. Association between oxidative stress in pregnancy and preterm premature rupture of membranes. Clin Biochem. 2007; 40(11): 793-797. https://doi.org/10.1016/j.clinbiochem.2007.03.004
25. Mistry, H., Williams, P. The Importance of Antioxidant Micronutrients in Pregnancy. Oxid Med Cell Longev. 2011; 2011: ID 841749. https://doi.org/10.1155/2011/841749
26. Zachara B, Wardak C, Didkowski W, Maciag A, Marchaluk E. Changes in blood selenium and glutathione concentrations and glutathione peroxidase activity in human pregnancy. Gynecol Obstet Invest. 1993; 35(1): 12-17. https://doi.org/10.1159/000292655
27. Vakelic J, Kapamadzija A, Petrovic D, Grujic Z, Novakov-Mikic A, Kopitovic V, Bjelica A. Variations of Serum Copper Values in Pregnancy. Srp Arh Celok Lek. 2012; 140(1-2): 42-46. https://doi.org/10.2298/SARH1202042V
28. Wang H, Hu Y, Hao J, Chen Y, Su P, Wang Y, Yu Y, et al. Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Sci Rep. 2015; 5: 11626. https://doi.org/10.1038/srep11262
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