How to Cite
1.
Vílchez León M, Cortés Mejía M, Espinoza Artavia A, Webb Webb K. Unicentric Castleman disease: brief review of an uncommon disease. Rev.méd.sinerg. [Internet]. 2019Feb.1 [cited 2024Jul.3];4(2):28 - 36. Available from: https://revistamedicasinergia.com/index.php/rms/article/view/197
Abstract
Castleman’s disease is a rare pathological entity, which comprises a heterogeneous group of histopathological disorders of the lymph nodes. It can be classified as unicentric Castleman’s disease, when it involves the growth of a single lymph node or lymph nodes of the same region, or in multicentric Castleman’s disease if it affects adenopathies of different ganglionic regions. Both types of Castleman’s disease differ in incidence, epidemiology, and clinical course. The unicentric Castleman disease has an estimated incidence in the United States between 15.9 to 19.9 cases per million person-years, occurs mainly in young people, around the third decade of life and is more frequent in women. The causal factors of this pathology are unknown. The clinical manifestations depend on the histological variant, with the hyaline vascular variant being more frequent, which is usually asymptomatic. The confirmatory diagnosis of the unicentric Castleman disease is histological. Complete nodular resection is the treatment of choice, while radiotherapy and chemotherapy are therapeutic options for non-resectable lesions. The prognosis of the disease is benign, with an associated mortality to 10 years of 4% and percentages of cure around 95%.
Keywords
Castleman disease. lymph nodes. lymphadenopathy. Fluorodeoxyglucose F18.
References
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13. Stone K, Woods E, Szmania S, Stephens O, Garg T, Barlogie B, Shaughnessy J, Hall B, Reddy M, Hoering A, Hansen E, van Rhee F. Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman Disease and is associated with increased soluble interleukin-6 receptor levels. PLoS One. 2013; 8(1): e54610. https://doi.org/10.1371/journal.pone.0054610
14. Mitsos S, Stamatopoulos A, Patrini D, George R, Lawrence D, Panagiotopoulos N. The role of surgical resection in Unicentric Castleman’s disease: A systematic review. Adv Respir Med. 2018; 86(1): 36-43. https://doi.org/1010.5603/ARM.2018.0008
15. Rassouli N, Obmann V, Sandhaus L, Herrmann K. (18F)-FDG-PET/MRI of unicentric retroperitoneal Castleman disease in a pediatric patient. Clinical Imaging. 2018 Jul-Aug; 50(1): 175-180. https://doi.org/10.1016/j.clinimag.2018.03.010
16. Van Rhee F, Greenway A, Stone K. Treatment of idiopathic Castleman disease. Hematol Oncol Clin North Am. 2018 Feb; 32(1): 89-106. https://doi.org/10.1016/j.hoc.2017.09.008
17. Ren N, Ding L, Jia E, Xue J. Recurrence in unicentric Castleman’s disease postoperatively: a case report and literature review. BMC Surgery. 2018; 18(1): 1-5. https://doi.org/10.1186/s12893-017-0334-7
18. Parra R, Guio J, Lopez P. Localized Castleman’s disease in the breast in a young woman. Case Rep Pathol. 2016; 2016: 8413987. https://doi.org/10.1155/2016/8413987
19. Le A, Shan L, Wang Z, Dai X, Xiao T, Zhuo R, Yuan R. Laparoscopic treatment for retroperitoneal hyaline-vascular type localized Castleman’s disease (LCD) in the iliac vessel region. Int J Clin Exp Med. 2015 Nov 15; 8(11): 19948-19953. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723752/
20. Talat N, Belgaumkar A, Schulte K. Surgery in Castleman’s disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr; 255(4): 677-84. https://doi.org/10.1097%2FSLA.0b013e318249dcdc.
2. Sevilla D, Frias C, Ortiz C. Enfermedad de Castleman. Análisis histopatológico e inmunohistoquímico de treinta y nueve casos. Gac Med Mex. 2017; 153: 550-558. https://doi.org/10.24875/GMM.17003021
3. Wong R. Unicentric Castleman Disease. Hematol Oncol Clin N Am. 2018 Feb; 32(1): 65–73. https://doi.org/10.1016/j.hoc.2017.09.006
4. Liu A, Nabel C, Finkelman B, Ruth J, Kurzrock R, van Rhee F, Krymskaya V, Kelleher D, Rubenstein A, Fajgenbaum D. Idiopathic multicentric Castleman’s disease: a systematic literature review. Lancet Haematol. 2016 Apr; 3(4): 163-175. https://doi.org/10.1016/S2352-3026(16)00006-5
5. Wu D, Lim M, Jaffe E. Pathology of Castleman Disease. Hematol Oncol Clin N Am. 2018; 32(1): 37–52. https://doi.org/10.1016/j.hoc.2017.09.004
6. Marco C, Méndez R, Aliste C, Fraga M, Bautista A. Enfermedad de Castleman cervical pediátrica. Acta Otorrinolaringol Esp. 2018; 69(2): 117-119. https://doi.org/10.1016/j.otorri.2017.03.003
7. Fajgenbaum D. Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease. Blood. Nov 2018; 132(22): 2323-2330. https://doi.org/10.1182/blood-2018-05-848671
8. Zhang X, Rao H, Xu X, Zhihua L, Bing L, Wu H, Li M, Tong X, Li J, Cai Q. Clinical characteristics and outcomes of Castleman disease: A multicenter study of 185 Chinese patients. Cancer Sci. 2017; 109(1): 199-206. https://doi.org/10.1111/cas.13439
9. Simpson D. Epidemiology of Castleman Disease. Hematol Oncol Clin N Am. 2018; 32 (1): 1–10. https://doi.org/10.1016/j.hoc.2017.09.001
10. Fiedler E, Gourzong C, Goyenaga P, López J. Enfermedad de Castleman. Reporte de 14 casos de 1990-2002 en el “Hospital Dr. Rafael Angel Calderón Guardia”, dos con presentación inusual y revisión de literatura. Acta méd. costarric. 2005 Jul-Sep; 47(3): 137-143. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0001-60022005000300007
11. Yu L, Tu M, Cortes J, Xu-Monette Z, Miranda R, Zhang J, Orlowski R, Neelapu S, Boddu P, Akosile M, Uldrick T, Yarchoan R, Medeiros L, Li Y, Fajgenbaum D, Young K. Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease. Blood. 2017; 129(12): 1658-1668. https://doi.org/10.1182/blood-2016-11-748855
12. García K, Rodríguez A. Unicentric Castleman’s Disease: Case Report and Literature Review. Canc Therapy & Oncol Int J. 2018 Mar; 9(5): 555775. https://doi.org/10.19080/CTOIJ.2018.09.555775
13. Stone K, Woods E, Szmania S, Stephens O, Garg T, Barlogie B, Shaughnessy J, Hall B, Reddy M, Hoering A, Hansen E, van Rhee F. Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman Disease and is associated with increased soluble interleukin-6 receptor levels. PLoS One. 2013; 8(1): e54610. https://doi.org/10.1371/journal.pone.0054610
14. Mitsos S, Stamatopoulos A, Patrini D, George R, Lawrence D, Panagiotopoulos N. The role of surgical resection in Unicentric Castleman’s disease: A systematic review. Adv Respir Med. 2018; 86(1): 36-43. https://doi.org/1010.5603/ARM.2018.0008
15. Rassouli N, Obmann V, Sandhaus L, Herrmann K. (18F)-FDG-PET/MRI of unicentric retroperitoneal Castleman disease in a pediatric patient. Clinical Imaging. 2018 Jul-Aug; 50(1): 175-180. https://doi.org/10.1016/j.clinimag.2018.03.010
16. Van Rhee F, Greenway A, Stone K. Treatment of idiopathic Castleman disease. Hematol Oncol Clin North Am. 2018 Feb; 32(1): 89-106. https://doi.org/10.1016/j.hoc.2017.09.008
17. Ren N, Ding L, Jia E, Xue J. Recurrence in unicentric Castleman’s disease postoperatively: a case report and literature review. BMC Surgery. 2018; 18(1): 1-5. https://doi.org/10.1186/s12893-017-0334-7
18. Parra R, Guio J, Lopez P. Localized Castleman’s disease in the breast in a young woman. Case Rep Pathol. 2016; 2016: 8413987. https://doi.org/10.1155/2016/8413987
19. Le A, Shan L, Wang Z, Dai X, Xiao T, Zhuo R, Yuan R. Laparoscopic treatment for retroperitoneal hyaline-vascular type localized Castleman’s disease (LCD) in the iliac vessel region. Int J Clin Exp Med. 2015 Nov 15; 8(11): 19948-19953. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723752/
20. Talat N, Belgaumkar A, Schulte K. Surgery in Castleman’s disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr; 255(4): 677-84. https://doi.org/10.1097%2FSLA.0b013e318249dcdc.
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