Manejo de infertilidad por anovulación en síndrome de ovario poliquístico
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Otoya Chaves F, León Quirós S, Rodríguez Morera M. Manejo de infertilidad por anovulación en síndrome de ovario poliquístico. Rev.méd.sinerg. [Internet]. 1 de febrero de 2021 [citado 19 de junio de 2021];6(2):e642. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/642

Resumen

La infertilidad por anovulación es una complicación común asociada al síndrome de ovario poliquístico. La optimización de la salud constituye el primer paso en el abordaje de esta patología, principalmente con cambios en estilo de vida e índice de masa corporal óptimo. En lo referente a farmacoterapia, el citrato de clomifeno es ampliamente utilizado a nivel mundial como primera línea para inducir la ovulación. No obstante, el letrozol y la metformina en combinación con citrato de clomifeno, son terapias con evidencia prometedora que han demostrado ser superiores al citrato de clomifeno en monoterapia, en lo que respecta a fertilidad. Sin embargo, no existe consenso, y se siguen considerando terapias de segunda línea. Las gonadotropinas exógenas y la perforación laparoscópica del ovario son utilizadas cuando hay resistencia a la primera línea. La fertilización in vitro es una opción cuando tanto la primera, como la segunda línea, no son exitosas. Otros medicamentos se encuentran en estudio para determinar su eficacia en esta patología, como los agonistas del receptor del péptido similar al glucagón tipo 1 y esteroisómeros del inositol, empero, aún requieren estudios de mejor calidad.

https://doi.org/10.31434/rms.v6i2.642

Palabras clave

anovulación. infertilidad. síndrome de ovario poliquístico. clomifeno. letrozol.
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