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El síndrome fiebre periódica, estomatitis aftosa, faringitis y adenitis cervical (PFAPA) es un tipo frecuente de fiebre recurrente en infantes. Entre las opciones de tratamiento se encuentran: antiinflamatorios no esteroideos, cimetidina, esteroides, colchicina y la amigdalectomía. La colchicina funciona como un modulador del sistema inmunológico, sin producir inmunosupresión, y es el tratamiento profiláctico de elección en el PFAPA, disminuyendo la duración e intensidad de las crisis febriles y aumentando el intervalo entre episodios.
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