Dermatomiositis como síndrome paraneoplásico

Palabras clave: dermatomiositis, neoplasias, autoanticuerpos

Resumen

Las miopatías inflamatorias tienen un riesgo aumentado de malignidad, siendo la dermatomiositis la de mayor asociación. La neoplasia puede ser sólida o hematológica. Existen factores clínicos y de laboratorio que pueden aumentar o disminuir el riesgo de presentación de miositis como enfermedad paraneoplásica. Entre los principales factores de riesgo, se ha observado la presencia de anticuerpos anti-TIF1, el anti-NXP2 y en menor medida el anti-SAE. La principal teoría de su origen apunta hacia la respuesta inmune derivada de la creación de proteínas mutadas por parte de las células cancerosas. El diagnóstico de malignidad se puede realizar antes, durante o después del diagnóstico de dermatomiositis. No existe un régimen terapéutico establecido, sin embargo se ha propuesto el uso de esteroides, inmunosupresores o inmunoglobulinas, así como la terapia efectiva contra el cáncer.

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Biografía del autor/a

Dra. Andrea Hernández Valverde, Hospital Dr. Max Terán Valls, Puntarenas, Costa Rica

Médico general, graduada de la Universidad de Costa Rica (UCR). cod. MED15870. Correo: andherval17@gmail.com

Dr. Luis Esteban Arriola Acuña, Área de salud de Coto Brus, Puntarenas, Costa Rica

Médico general, graduado de la Universidad de Costa Rica (UCR) . cod. MED15897. Correo: esteban.arriola@gmail.com 

Dra. Amanda Vargas Guzmán, Investigadora Independiente, San José, Costa Rica

Médica general, graduada de la Universidad de Costa Rica (UCR). cod. MED16540. Correo: amandavargas93@gmail.com

Citas

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Publicado
2020-07-01
Cómo citar
1.
Hernández Valverde A, Arriola Acuña LE, Vargas Guzmán A. Dermatomiositis como síndrome paraneoplásico. Rev.méd.sinerg. [Internet]. 1 de julio de 2020 [citado 10 de agosto de 2020];5(7):e534. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/534
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