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Abstract
The following review offers a general approach from the dermatologic and rheumatologic point of view to the Juvenile Dermatomyositis disease (DMJ). DMJ is a systemic autoimmune disease, characterized by myositis of proximal muscles along with characteristic skin lesions. It usually appears at a very young age and affects more females than males. Its etiology has been associated with specific genetic and environmental factors. Besides skin and lungs, other affected organs include lungs, heart and vessels, and gastrointestinal tract. Currently, diagnosis is based on clinical manifestations, magnetic resonance and specific autoantibodies. Calcinosis is one of the most frequent and devastating complications of the disease. Treatment focuses on prompt start of corticosteroids at high doses. Disease-modifying drugs are used along with corticosteroids in more severe cases. Nowadays, prognosis of DMJ shows a decline in mortality since the establishment of the corticosteroid era.
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References
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