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Abstract
Ovarian choriocarcinoma is a germ cell tumor with very low incidence, which can be gestational or non-gestational depending on its etiology. Patients present a variety of symptoms, from abdominal pain, abnormal uterine bleeding, secondary effects of elevated hCG to secondary symptoms of metastases, frequently in the lung and brain. Its diagnosis is very difficult and tends to be confused with other ovarian pathologies. Ultrasound, as well as pathological and genetic studies, are generally needed to make an accurate diagnosis. They are generally treated with cycles of chemotherapy and surgical management. Survival depends on the stage at the time of diagnosis.
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References
Peng H, Li L, Bi Y. Successful management of nongestational ovarian choriocarcinoma complicated with choriocarcinoma syndrome: A case report and a literature review. Curr Probl Cancer [Internet]. 2020 [citado el 17 de diciembre de 2021]; 44(4): 100539. Disponible en: http://dx.doi.org/10.1016/j.currproblcancer.2020.100539
WHO classification of tumours [Internet]. Iarc.fr. [citado el 10 de enero de 2022]. Disponible en: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours
Kucera C, Cox-Bauer C, Miller C. Apparent ectopic pregnancy with unexpected finding of a germ cell tumor: A case report. Gynecologic Oncology Reports. 2017 [citado el 8 de diciembre de 2021]; 21(3):31-33. Disponible en http://dx.doi.org/10.1016/j.gore.2017.05.004
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P. Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma. Arch Gynecol Obstet [Internet]. 2020 [citado el 18 de diciembre de 2021] ;301(4):901–12. Disponible en: http://dx.doi.org/10.1007/s00404-020-05502-9
Zhu C, Liu H, Wei Y, Shen Z, Qian L, Song W et al. Low-risk gestational trophoblastic neoplasia outcome after treatment with VMP regimen from 2005 to 2017. Taiwanese Journal of Obstetrics and Gynecology. 2019 [citado el 8 de diciembre de 2021] ;58(3):332-337. Disponible en https://doi.org/10.1016/j.tjog.2019.03.008
Zhang X, Yan K, Chen J, Xie X. Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series. Diagn Pathol [Internet]. 2019 [citado el 10 de diciembre de 2021];14(1):93. Disponible en: http://dx.doi.org/10.1186/s13000-019-0866-5
Jia N, Chen Y, Tao X, Ou E, Lu X, Feng W. A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. J Ovarian Res [Internet]. 2017 [citado el 8 de diciembre de 2021]; 10(1). Disponible en: http://dx.doi.org/10.1186/s13048-017-0334-3
Maestá I, Ramírez LAC, de Mello JBH, Rudge MVC, Rogatto SR. Genetic characterization of choriocarcinoma and potential clinical implications. Clinics in Oncology - Gynecological Cancers/Oncology [Internet]. 2017.[citado el 11 de noviembre de 2021];2. Disponible en: http://www.clinicsinoncology.com/full-text/cio-v2-id1261.php
Kazemi S, Raoufi M, Moghaddam N, Tabatabaeefar M, Ganjooei T. Ovarian ectopic pregnancy misdiagnosed as gestational choriocarcinoma: A case report. Annals of Medicine and Surgery. 2022 [citado el 8 de marzo de 2022];73(4):103236 Disponible en http://dx.doi.org/10.1016/j.amsu.2021.103236
Duong J, Ghanchi H, Miulli D, Kahlon A. Metastatic nongestational choriocarcinoma to the brain: Case report and proposed treatment recommendations. World Neurosurg [Internet]. 2018 [citado el 8 de noviembre de 2021];115:170–5. Disponible en: http://dx.doi.org/10.1016/j.wneu.2018.04.050
Crum CP, Nucci MR, Granter SR, Howitt BE, Parast MM, Boyd T, et al. Diagnostic gynecologic and obstetric pathology [Internet]. 3a ed. Elsevier; 2017 [citado el 11 de noviembre de 2021]. Disponible en: https://books.google.at/books?id=rFk6DwAAQBAJ
Irene M, Njoroge M, Inyangala D, Caroline M, Mariga D, Waweru W, et al. Pure non-gestational ovarian choriocarcinoma. J Pediatr Surg Case Rep [Internet]. 2019 [citado el 14 de noviembre de 2021];40:1–5. Disponible en: http://dx.doi.org/10.1016/j.epsc.2018.10.005
Op T, Ghosh A. Ovarian tumors: Pattern of histomorphological types-A 10 years study in a tertiary referral center and review of literature [Internet].2016. Com.np. [citado el 8 de marzo de 2022]. Disponible en: http://www.kumj.com.np/issue/54/153-158.pdf
Aranake-Chrisinger J, Huettner P, Hagemann A, Pfeifer J. Use of short tandem repeat analysis in unusual presentations of trophoblastic tumors and their mimics. Human Pathology. 2016 [citado el 18 de noviembre de 2021];52(3):92-100. Disponible en http://dx.doi.org/10.1016/j.humpath.2016.01.005
Magnaeva A, Asaturova A, Tregubova A, Matsneva I, Solopova A. Non-gestational choriocarcinoma of ovary: Clinico-morphological features and diagnostic value of DNA polymorphism study. Human Pathology Reports. 2022 [citado el 8 de marzo de 2022];27(1):300593. Disponible en https://doi.org/10.1016/j.hpr.2022.300593
Kaur B. Pathology of malignant ovarian germ cell tumours. Diagn Histopathol (Oxf) [Internet]. 2020 [citado el 14 de diciembre de 2021]; Disponible en: http://dx.doi.org/10.1016/j.mpdhp.2020.03.006
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM. Choriocarcinoma in women: Analysis of a case series with genotyping. Am J Surg Pathol [Internet]. 2017 [citado el 14 de noviembre de 2021];41(12):1593–606. Disponible en: http://dx.doi.org/10.1097/PAS.0000000000000937
Mascilini F, Moro F, Di Grazia FM, Leombroni M, Distefano M, Fanfani F, et al. Clinical and ultrasound features of non-gestational ovarian choriocarcinoma. Ultrasound Obstet Gynecol [Internet]. 2017 [citado el 14 de noviembre de 2021];52(1):121–3. Disponible en: http://dx.doi.org/10.1002/uog.18943
Quagliozzi L, Lo Presti V, Arciuolo D, Mascilini F. Ultrasound, macroscopic and histological features of malignant ovarian tumors. Non-epithelial ovarian carcinomas: tubal choriocarcinoma and granulosa cell tumor. International Journal of Gynecologic Cancer. 2020 [citado el 20 de noviembre de 2021]; 31(7):ijgc-2020-001875. Disponible en http://dx.doi.org/10.1136/ijgc-2020-001875
Lee A, Im Y, Shim S, Lee S, Kim T, So K. Successful Treatment of Nongestational Choriocarcinoma in a 15-Year-Old Girl: A Case Report. Journal of Pediatric and Adolescent Gynecology. 2021 [citado el 08 de enero de 2022];34(2):231-233. Disponible en https://doi.org/10.1016/j.jpag.2020.11.004
Euscher E. Germ Cell Tumors of the Female Genital Tract. Surgical Pathology Clinics. 2019 [citado el 21 de noviembre de 2021];12(2):621-649.Disponible en https://doi.org/10.1016/j.path.2019.01.005
Lee A, Im Y, Shim S, Lee S, Kim T, So K. Successful Treatment of Nongestational Choriocarcinoma in a 15-Year-Old Girl: A Case Report. Journal of Pediatric and Adolescent Gynecology. 2021 [citado el 14 de enero de 2022];34(2):231-233. Disponible en https://doi.org/10.1016/j.jpag.2020.11.004
Mello JBH de, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, et al. Genomic profile in gestational and non-gestational choriocarcinomas. Placenta [Internet]. 2017 [citado el 19 de noviembre de 2021];50:8–15. Disponible en: http://dx.doi.org/10.1016/j.placenta.2016.12.009
Banet N, Gown AM, Shih I-M, Kay Li Q, Roden RBS, Nucci MR, et al. GATA-3 expression in trophoblastic tissues: An immunohistochemical study of 445 cases, including diagnostic utility. Am J Surg Pathol [Internet]. 2015 [citado el 8 de marzo de 2022];39(1):101–8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25188865/
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