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Abstract
Older adults represent a growing percentage of the world's population, and the use of antimicrobials in this age group is quite frequent. For this reason, understanding the changes involved with aging and the impact they have on these drugs allows them to be used appropriately, leading to the lowest possible rate of complications and avoiding the development of multi-resistant germs. As age advances, important changes occur in the gastrointestinal tract and the renal system, which have a major influence on the way a drug is absorbed, metabolized and excreted, as well as the desired effect it will have on the body. Increasing disease prevalence, as well as age-independent factors such as lifestyle, may further influence pharmacological effects. In addition, given the frequent polypharmacy in the elderly, the risk of drug interactions is another important factor to take into account prior to prescribing any medication.
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References
Pea F. Pharmacokinetics and drug metabolism of antibiotics in the elderly. Expert Opin Drug Metab Toxicol [Internet]. 2018;14(10):1087–100. Disponible en: http://dx.doi.org/10.1080/17425255.2018.1528226
Giarratano A, Green SEL, Nicolau DP. Review of antimicrobial use and considerations in the elderly population. Clin Interv Aging [Internet]. 2018;13:657–67. Disponible en: http://dx.doi.org/10.2147/cia.s133640
Buowari YD. Antibiotic resistance in the elderly. J Ageing Res Healthc [Internet]. 2017;1(4):11–4. Disponible en: http://dx.doi.org/10.14302/issn.2474-7785.jarh-16-1396
Chandrasekhar D, Manaparambil H, Parambil JC. Outcome assessment of intervention on appropriateness of antibiotic use among geriatric patients: A prospective interventional study from a tertiary care referral hospital. Clin Epidemiol Glob Health [Internet]. 2019;7(4):536–41. Disponible en: http://dx.doi.org/10.1016/j.cegh.2018.12.005
Reeve E, Trenaman SC, Rockwood K, Hilmer SN. Pharmacokinetic and pharmacodynamic alterations in older people with dementia. Expert Opin Drug Metab Toxicol [Internet]. 2017;13(6):651–68. Disponible en: http://dx.doi.org/10.1080/17425255.2017.1325873
Andres TM, McGrane T, McEvoy MD, Allen BFS. Geriatric pharmacology: An update. Anesthesiol Clin [Internet]. 2019;37(3):475–92. Disponible en: http://dx.doi.org/10.1016/j.anclin.2019.04.007
Raman M, Middleton RJ, Kalra PA, Green D. Estimating renal function in old people: an in-depth review. Int Urol Nephrol [Internet]. 2017;49(11):1979–88. Disponible en: http://dx.doi.org/10.1007/s11255-017-1682-z
Aloy B, Launay-Vacher V, Bleibtreu A, Bortolotti P, Faure E, Filali A, et al. Antibiotics and chronic kidney disease: Dose adjustment update for infectious disease clinical practice. Med Mal Infect [Internet]. 2020;50(4):323–31. Disponible en: http://dx.doi.org/10.1016/j.medmal.2019.06.010
Distribución del fármaco en los tejidos [Internet]. Manual MSD versión para profesionales. [citado el 28 de enero de 2022]. Disponible en: https://www.msdmanuals.com/es/professional/farmacolog%C3%ADa-cl%C3%ADnica/farmacocin%C3%A9tica/distribuci%C3%B3n-del-f%C3%A1rmaco-en-los-tejidos
Benson JM. Antimicrobial pharmacokinetics and pharmacodynamics in older adults. Infect Dis Clin North Am [Internet]. 2017;31(4):609–17. Disponible en: http://dx.doi.org/10.1016/j.idc.2017.07.011
Gallagher JC, MacDougall C. Antibiotics Simplified. 4a ed. Sudbury, MA, Estados Unidos de América: Jones and Bartlett; 2018.
Nau R, Seele J, Djukic M, Eiffert H. Pharmacokinetics and pharmacodynamics of antibiotics in central nervous system infections. Curr Opin Infect Dis [Internet]. 2018;31(1):57–68. Disponible en: http://dx.doi.org/10.1097/qco.0000000000000418
de Lastours V. Rev Med Interne [Internet]. 2017;39(3):171–7. Disponible en: http://dx.doi.org/10.1016/j.revmed.2017.06.009
Levey AS, Inker LA. Assessment of glomerular filtration rate in health and disease: A state of the art review: State of the art review for clinical pharmacology and therapeutics. Clin Pharmacol Ther [Internet]. 2017;102(3):405–19. Disponible en: http://dx.doi.org/10.1002/cpt.729
Falcone M, Paul M, Tiseo G, Yahav D, Prendki V, Friberg LE, et al. Considerations for the optimal management of antibiotic therapy in elderly patients. J Glob Antimicrob Resist [Internet]. 2020;22:325–33. Disponible en: http://dx.doi.org/10.1016/j.jgar.2020.02.022
Rybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, Liu C, et al. Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm [Internet]. 2020;77(11):835–64. Disponible en: http://dx.doi.org/10.1093/ajhp/zxaa036
Eyler RF, Shvets K. Clinical pharmacology of antibiotics. Clin J Am Soc Nephrol [Internet]. 2019;14(7):1080–90. Disponible en: http://dx.doi.org/10.2215/CJN.08140718
Yoshikawa TT, Norman DC. Geriatric infectious diseases: Current concepts on diagnosis and management. J Am Geriatr Soc [Internet]. 2017;65(3):631–41. Disponible en: http://dx.doi.org/10.1111/jgs.14731
Arnold FW. How antibiotics should be prescribed to hospitalized elderly patients with community-acquired pneumonia. Drugs Aging [Internet]. 2017;34(1):13–20. Disponible en: http://dx.doi.org/10.1007/s40266-016-0423-9
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