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Abstract
The glomerular filtration rate (GFR) is the product of the number of nephrons multiplied by the mean glomerular filtration rate of a single nephron. This measure in the elderly is conditioned by a series of factors that lead to the erroneous diagnosis of kidney disease, without taking into account the changes that the kidney undergoes with aging. The use of different endogenous markers such as creatinine is subject to the decrease in muscle mass and diet, however, its ease of measurement, its low cost and the wide availability of analysis, make it one of the most widely used in the clinical practice. Cystatin C is not affected by factors such as age, sex, race and muscle mass, so it is considered a better biomarker in geriatric patients, who have a great variability in their muscle composition. Currently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula is recommended by the latest Kidney Disease Improving Global Outcomes (KDIGO) guidelines of 2012 to estimate glomerular filtration rate. In addition, other CKD-EPI equations with cystatin C and CKD-EPI with creatinine-cystatin have been developed.
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References
Musso CG, Álvarez-Gregori J, Jauregui J, Macías-Núñez JF. Glomerular filtration rate equations: a comprehensive review. Int Urol Nephrol [Internet]. 2016;48(7):1105–10. Disponible en: http://dx.doi.org/10.1007/s11255-016-1276-1
Raman M, Middleton RJ, Kalra PA, Green D. Estimating renal function in old people: an in-depth review. Int Urol Nephrol [Internet]. 2017;49(11):1979–88. Disponible en: http://dx.doi.org/10.1007/s11255-017-1682-z
Levey AS, Inker LA. Assessment of glomerular filtration rate in health and disease: A state of the art review: State of the art review for clinical pharmacology and therapeutics. Clin Pharmacol Ther [Internet]. 2017;102(3):405–19. Disponible en: http://dx.doi.org/10.1002/cpt.729
Musso CG, de Los Rios E, Vilas M, Terrasa S, Bratti G, Varela F, et al. The HUGE formula (hematocrit, urea, gender) for screening for chronic kidney disease in elderly patients: a study of diagnostic accuracy. Int Urol Nephrol [Internet]. 2017;49(4):677–80. Disponible en: http://dx.doi.org/10.1007/s11255-016-1486-6
Zou L-X, Sun L, Nicholas SB, Lu Y, K SS, Hua R. Comparison of bias and accuracy using cystatin C and creatinine in CKD-EPI equations for GFR estimation. Eur J Intern Med [Internet]. 2020;80:29–34. Disponible en: http://dx.doi.org/10.1016/j.ejim.2020.04.044
Wang Y, Levey AS, Inker LA, Jessani S, Bux R, Samad Z, et al. Performance and determinants of serum creatinine and cystatin C-based GFR estimating equations in South Asians. Kidney Int Rep [Internet]. 2021;6(4):962–75. Disponible en: http://dx.doi.org/10.1016/j.ekir.2021.01.005
Heras M, Fernández-Reyes MJ. Nuevas herramientas para abordar la función renal en ancianos: la ecuación Berlin Initiative Study y la fórmula hematocrito, urea y género. Med Clin (Barc) [Internet]. 2016;146(10):450–4. Disponible en: http://dx.doi.org/10.1016/j.medcli.2016.01.012
Freidin N, O’Hare AM, Wong SPY. Person-centered care for older adults with kidney disease: Core Curriculum 2019. Am J Kidney Dis [Internet]. 2019;74(3):407–16. Disponible en: http://dx.doi.org/10.1053/j.ajkd.2019.01.038
Bargnoux A-S, Barguil Y, Cavalier E, Cristol J-P. Estimation of glomerular filtration rate using cystatin C. Ann Biol Clin (Paris) [Internet]. 2019;77(4):375–80. Disponible en: http://dx.doi.org/10.1684/abc.2019.1456
Pasala S, Carmody JB. How to use… serum creatinine, cystatin C and GFR. Arch Dis Child Educ Pract Ed [Internet]. 2017;102(1):37–43. Disponible en: http://dx.doi.org/10.1136/archdischild-2016-311062
Griffin BR, Liu KD, Teixeira JP. Critical care nephrology: Core Curriculum 2020. Am J Kidney Dis [Internet]. 2020;75(3):435–52. Disponible en: http://dx.doi.org/10.1053/j.ajkd.2019.10.010
Inker LA, Tighiouart H, Coresh J, Foster MC, Anderson AH, Beck GJ, et al. GFR estimation using β-trace protein and β2-microglobulin in CKD. Am J Kidney Dis [Internet]. 2016;67(1):40–8. Disponible en: http://dx.doi.org/10.1053/j.ajkd.2015.07.025
Li Z, Wang Z. Aging kidney and aging-related disease. Adv Exp Med Biol [Internet]. 2018;1086:169–87. Disponible en: http://dx.doi.org/10.1007/978-981-13-1117-8_11
Moore PK, Hsu RK, Liu KD. Management of acute kidney injury: Core curriculum 2018. Am J Kidney Dis [Internet]. 2018;72(1):136–48. Disponible en: http://dx.doi.org/10.1053/j.ajkd.2017.11.021
Mora-Gutiérrez JM, Slon Roblero MF, Castaño Bilbao I, Izquierdo Bautista D, Arteaga Coloma J, Martínez Velilla N. Rev Esp Geriatr Gerontol [Internet]. 2017;52(3):152–8. Disponible en: http://dx.doi.org/10.1016/j.regg.2016.03.006
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