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Abstract
Breast cancer is the most common malignant tumor in women and the leading cause of death in developed countries. Its incidence is increasing but its early diagnosis has managed to reduce mortality. In some cases, breast cancer is due to inherited genetic mutations. The tumor tissue of breast cancers related to mutations in the germ line requires a detailed histological and molecular study that determines the main characteristics of the tumor in order to establish risk, management, prognosis and survival of the patient. The genes most implicated with mutations in the germ line are BRCA1 and BRCA2. Those tumors associated with these mutations present more aggressive tumor characteristics in relation to those who do not carry a mutation, which is related to a worse prognosis.
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References
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