Peptic ulcer disease

Abstract

Peptic ulcer is one of the public health problems worldwide. Its pathophysiology is complex and multifactorial. Approximately 85% are due to H. pylori. The development of the disease is represented by an imbalance between chronic inflammatory damage, acid secretion and mucosal defense. The pivot symptom epigastric pain is described as burning, sometimes even as a stake. Most patients report worse in  the morning that gets better with antacids. The evaluation of patients with suspected peptic ulcer usually involves endoscopy, which is the method of choice for diagnosis. Current treatment of peptic ulcer in case involves a combination of an inhibitory drug proton pump with antibiotics.