Abstract
Congenital infection with cytomegalovirus (CMV) represents the leading cause of maternal fetal infection, also is the leading cause of childhood deafness worldwide.
Infected women can present a large number of events or asymptomatic.
Most newborns and infants are asymptomatic at birth, but can present late sequelae such as mental retardation, learning disabilities, cerebral palsy, epilepsy, partial or total deafness or blindness and visual deficits.
Mother diagnosis is based on the presence of antibodies in blood and fetal diagnosis is based on detection of immunocomplexes in amniotic fluid.
Treatment during pregnancy has been used antiviral drugs such as ganciclovir and valganciclovir orally.
Keywords
Cytomegalovirus. deafness. congenital. antibodies. immune complexes. ganciclovir.
References
1. Berger Problems and challenges in the diagnosis of vertical infection with human cytomegalovirus (CMV): Lessons from two accidental cases2011) 281– 284 Journal of Clinical Virology 51 www.elsevier.com/locate/jcv
2. Gabbe, S. et al. (2012). Obstetric. Normal and Problem Pregnancies. Sixth Edition. Editorial Saunders. Capitulo 50
3. L. Gabrielli1, et al 6 July 2012 Clinical Microbiology and Infection ª2012 European Society of Clinical Microbiology and Infectious Diseases, CMI, 18, E419–E427
4. G.Nigroa and Stuart P. Adlerb 2011 Cytomegalovirus infections during pregnancy 2011.Wolters Kluwer Health | Lippincott Williams & Wilkins 1-6
5. Williams Obstetricia Cunningham, Leveno, Bloom, Spong, Dashe, Hoffman, Casey, Sheffiield. 24th edition. | McGraw-Hill 2014, Capitulo 64.
2. Gabbe, S. et al. (2012). Obstetric. Normal and Problem Pregnancies. Sixth Edition. Editorial Saunders. Capitulo 50
3. L. Gabrielli1, et al 6 July 2012 Clinical Microbiology and Infection ª2012 European Society of Clinical Microbiology and Infectious Diseases, CMI, 18, E419–E427
4. G.Nigroa and Stuart P. Adlerb 2011 Cytomegalovirus infections during pregnancy 2011.Wolters Kluwer Health | Lippincott Williams & Wilkins 1-6
5. Williams Obstetricia Cunningham, Leveno, Bloom, Spong, Dashe, Hoffman, Casey, Sheffiield. 24th edition. | McGraw-Hill 2014, Capitulo 64.
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